DNA Evaluation of Fragments for Early Interception - | Clinical Research Studies Listing

Build status - In Progress

Recruiting

50 years - 99 years

All

2500 participants needed

1 Location

Brief description of study

The purpose of this study is to collect blood samples to determine if a blood-based test can be used to identify lung cancers that may or may not also be seen on images of lungs. Additionally, the study aims to see if a blood-based test can identify other types of cancers and health conditions. Approximately 2500 patients in the United States will participate in this study. This will include approximately 1600 patients with cancer (600 with lung cancer and 1000 with another type of cancer) and approximately 900 patients without cancer.

Detailed description of study

The overall goal is to develop a cfDNA fragmentation-based algorithm with clinical performance metrics optimized to improve adherence to lung cancer screening guidelines while improving the benefits to harms ratio of serial LDCT surveillance. The specific objective is to train and test a novel classifier using a multi-site, observational study design. This is a prospectively enrolling observational case-control study. Peripheral blood will be collected from individuals enrolled in the cohort.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research
Age: 50 years - 99 years
Gender: All

Age >= 50 and Smoking history which meets the U.S. Preventive Services Task Force (USPSTF) criteria of being high risk for developing lung cancer.

Updated on 04 Aug 2024. Study ID: 849987

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