The purpose of this study (ALLFTD) is to understand how Frontotemporal Lobar Degeneration (FTLD) syndromes progress over time, and to develop new tools to help with diagnosis and eventual treatment. The study is enrolling patients with FTLD syndromes. Additionally, the study is enrolling healthy members of families where there is a strong family history of FTLD or known FTLD-associated genetic mutation. Participating in the longitudinal arm of ALLFTD involves annual visits to an ALLFTD clinical site. These visits usually span 2-3 days, and involve a neurological exam; tests of memory, behavior, and judgement; a blood draw, imaging of your brain (MRI), and a lumbar puncture (LP). All participants enrolled in ALLFTD will have their DNA (from the blood draw) tested for FTLD-associated genetic mutations.

You may be eligible for this study if you meet the following criteria:

• Conditions: Frontotemporal Dementia
• Age: 30 years - 99 years
• Gender: All