Early Diagnosis of TTR Amyloid | Clinical Research Studies Listing

Build status - In Progress

Recruiting

40 years - 75 years

All

Phase N/A

100 participants needed

1 Location

Brief description of study

The purpose of this study is to find out if we can detect a disease of the heart called cardiac transthyretin (TTR) amyloidosis early. People develop cardiac TTR amyloidosis due to an accumulation of a transthyretin protein in the heart. This can happen as part of an aging process (wild type TTR) or this could happen due to a genetic cause. The protein can deposit in the heart and tendons of the elderly person. Inherited mutant protein can result from a genetic mutation that results in misfolded proteins accumulating in multiple parts of the body including the nerves, heart, and the gastrointestinal tract.

In this study, we will screen two patient populations. One group is African Americans with slightly thickened heart where mutant TTR gene can be as prevalent as 4%. The second group is of people who have been diagnosed with bilateral carpel tunnel syndrome.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: cardiac amyloidosis,amyloidosis,heart disease,hypertension,atrial fibrillation
Age: 40 years - 75 years
Gender: All

Exclusion Criteria may include but not limited to: 1. Those with a known diagnosis of Cardiac Amylodosis 2. Severe claustrophobia, 3. Pregnancy or nursing, 4. Other contraindications for cardiac MRI including but not limited to implantable pacemakers, ICDs, neurostimulators, other metallic objects that deemed unsafe for MRI.

Updated on 04 Aug 2024. Study ID: 834188

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