Evaluation of In Vivo Neuroinflammation in Alzheimers Disease Using Novel Positron Emission Tomography (PET/CT) Imaging
Enrolling By Invitation
18 years - 99 years
All
Phase
1
10 participants needed
1 Location
Brief description of study
PET/CT imaging will be used to evaluate neuroinflammation in
subjects with Alzheimer's Disease and Healthy Controls, using the
investigational radiotracers [11C]PBR28 and[18F]NOS. Each subject will
have one PET/CT session that includes both [11C]PBR28 and [18F]NOS
injections and scan of the brain performed sequentially. Subjects may
also undergo a brain MRI if they have not had an adequate MRI within 6
months or 1 year of enrollment.
We plan to enroll adult subjects in this study, patients with a diagnosis of Alzheimer's Disease or mild cognitive impairment (AD cohort) and Healthy Controls (HC cohort) that are part of the UPenn Alzheimer's Disease Center (ADC) research cohort.
Subjects will also have a brain MRI scan if they have not had one within 6 months or 1 year of the PET scan visit.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: alzheimers,healthy volunteers
-
Age: 18 years - 99 years
-
Gender: All
Updated on
04 Aug 2024.
Study ID: 834090
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