Build status - In Progress

A Phase II Study of the Anti-GITR Agonist INCAGN01876 and the PD-1 Inhibitor INCMGA00012 in Combination with Stereotactic Radiosurgery in Recurrent Glioblastoma

Recruiting
99 years or below
All
Phase 2
32 participants needed
1 Location

Brief description of study

The following protocol is a phase II study of the combination of the GITR agonist monoclonal antibody INCAGN01876, the anti-PD1 monoclonal antibody INCMGA00012, and SRS for recurrent GBM. We hypothesize that the proposed regimen will be safe and stimulate a robust anti-tumor immune response and result in improved tumor responses. The purpose of this protocol is to determine the efficacy of the combination of INCMGA00012, INCAGN01876, and SRS in recurrent GBM, as measured by the overall objective response rate (ORR). INCAGN01876 (anti-GITR) 300mg will be administered IV every 2 weeks until disease progression, unacceptable toxicity, or 2 years, whichever occurs first. INCMGA00012 (anti-PD1) 500mg will be administered IV every 4 weeks until disease progression, unacceptable toxicity, or 2 years, whichever occurs first.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Medical Research
  • Age: 99 years or below
  • Gender: All
Updated on 12 Dec 2019. Study ID: 834197

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